I have been having all sorts of trouble with Hulu on my new Ubuntu desktop. When it does work it has a great fullscreen display. But the fullscreen mode would not work quite often. And when it did work it would always choose the smaller of my two monitors no matter what I did. The Popout option was nice and I could move it to the monitor I wanted but the control (pause, restart etc.) wouldn't work.
In trying to find solutions to these bugs I stumbled across Hulu desktop for Linux (including an Ubuntu 64 bit option). It works very well. The interface for Hulu desktop is flashy and nice in some ways but in some ways it is not easy to navigate. For example, it is much easier to see a list of the episodes you have subscribed to and their expiration dates.
And I get to watch programs like Caprica that I couldn't otherwise, since I don't have cable TV.
Related: Embedded YouTube Videos Won't Play - Using Multiple Firefox Profiles at the Same Time in Ubuntu
Problem: Hulu full-screen mode fails on Ubuntu in Firefox, Chrome and Opera. Hulu popout screen controls fail - Ubuntu 9.04, 64-bit. How to move a Hulu fullscreen to another monitor (using Hulu Desktop you can choose which monitor to use).